Reduced-intensity conditioningīased on your age and health history, you may receive lower doses or different types of chemotherapy or radiation for your conditioning treatment. You may be able to take medications or other measures to reduce such side effects. Organ complications, such as heart, liver or lung failure. ![]() Side effects of the conditioning process can include: You may have both chemotherapy and radiation or just one of these treatments as part of your conditioning treatment. The type of conditioning process you receive depends on several factors, including the disease being treated, your overall health and the type of transplant planned. Prepare your bone marrow for the new stem cells.Destroy cancer cells if you're being treated for cancer that may spread to other parts of the body.During conditioning, you'll undergo chemotherapy and possibly radiation to: The conditioning processĪfter completing the pretransplant tests and procedures, you'll begin a process known as conditioning. The blood from these cords is frozen and stored in a cord blood bank until needed for a bone marrow transplant. Mothers can choose to donate umbilical cords after their babies' births. Your transplant team decides which is better for you based on your situation.Īnother type of allogeneic transplant uses stem cells from the blood of umbilical cords (cord blood transplant). Stem cells can come from your donor's blood or bone marrow. Once a donor is found, stem cells are gathered from that person for the transplant. If you're having a transplant using stem cells from a donor (allogeneic transplant), you'll need a donor. Collecting stem cells for allogeneic transplant The remaining blood is returned to your body. These stem cells are collected and frozen for future use in the transplant. The machine separates your blood into different parts, including stem cells. If a transplant using your own stem cells (autologous transplant) is planned, you'll undergo a procedure called apheresis (af-uh-REE-sis) to collect blood stem cells.īefore apheresis, you'll receive daily injections of growth factor to increase stem cell production and move stem cells into your circulating blood so that they can be collected.ĭuring apheresis, blood is drawn from a vein and circulated through a machine. Collecting stem cells for autologous transplant Your transplant team will use the central line to infuse the transplanted stem cells, medications and blood products into your body. The catheter, often called a central line, usually remains in place for the duration of your treatment. In addition, a long, thin tube (intravenous catheter) will be implanted into a large vein in your chest or neck. The evaluation may take several days or more. The tests and procedures also ensure that you're physically prepared for the transplant. How you prepare Pretransplant tests and proceduresĪ series of tests and procedures can assess your general health and the status of your condition. Yellowing of the skin and the whites of your eyes.Skin changes, including scarring under the skin or skin stiffness.Chronic GVHD typically develops later and can affect many organs. It typically affects your skin, digestive tract or liver. Acute GVHD usually happens during the first months after your transplant. There are two kinds of GVHD: acute and chronic. But GVHD can happen to anyone who gets a bone marrow transplant from a donor. ![]() The risk of GVHD is greater if the stem cells come from an unrelated donor. Many people who have an allogeneic transplant get GVHD at some point. GVHD may happen at any time after your transplant. This condition occurs when the donor stem cells that make up your new immune system see your body's tissues and organs as something foreign and attack them. If you receive a transplant that uses stem cells from a donor (allogeneic transplant), you may be at risk of developing graft-versus-host disease (GVHD). Graft-versus-host disease: A potential risk when stem cells come from donors Together you can weigh the risks and benefits to decide whether a bone marrow transplant is right for you. Your health care provider can explain your risk of complications from a bone marrow transplant.
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